What question did this study set out to answer?

The aim is to classify patients with orthostatic disorders based on their early circulatory responses to standing.

August 1, 1991Clinical Science

Spectrum of orthostatic disorders: Classification based on an analysis of the short-term circulatory response upon standing

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Why the study?

Does beat-to-beat analysis of the initial circulatory response upon standing help classify orthostatic disorders?

Key Points

The aim is to classify patients with orthostatic disorders based on their early circulatory responses to standing.
Analyzed blood pressure and heart rate changes in 31 patients upon standing for 2 minutes.
Patients classified into three groups based on early steady-state responses; used continuous blood pressure measurement with Finapres.
Beat-to-beat analysis of initial circulatory response quantified changes in blood pressure and heart rate.
Group I showed normal blood pressure responses; group II had normal blood pressure with postural tachycardia (n=5); group III had hypotensive responses (n=9).
Recovery of blood pressure was present in all group I and II patients, absent in most of group III.
Relative bradycardia was less pronounced in groups II and III compared to group I.

Structured PICO

Does beat-to-beat analysis of the initial circulatory response upon standing help classify orthostatic disorders?

Population

31 consecutively referred patients (20 females, 11 males) with overt or suspected orthostatic disorders

Intervention

Beat-to-beat analysis of blood pressure and heart rate changes in the first 30 seconds to 2 minutes of standing

Outcome

Blood pressure and heart rate responses (initial drop, recovery, overshoot, maximum heart rate, relative bradycardia)surrogate

Beat-to-beat analysis of blood pressure changes in the first 30 seconds of standing is sufficient to classify abnormalities in orthostatic circulatory control.

Discussion

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Implication

May aid orthostatic disorder classification via initial 30-second BP recovery; leaves open prospective validation before practice change.

Cite This Study

Wieling et al. (1991) studied this question.

synapsesocial.com/papers/6a209e9f4e12e6ef5d9114f1 https://doi.org/10.1042/cs0810241

View Full Paper

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Spectrum of orthostatic disorders: Classification based on an analysis of the short-term circulatory response upon standing

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Spectrum of orthostatic disorders: Classification based on an analysis of the short-term circulatory response upon standing

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider