Key result
In ambulatory patients with HFrEF, pathological hemodynamic responses to orthostatic stress were significantly more frequent in those with office systolic blood pressure >140 mm Hg compared to ≤140 mm Hg (90.9% vs 53.9%, p=0.020).
Why the study?
The hemodynamic response to the active standing test and its association with office blood pressure and orthostatic intolerance symptoms in heart failure patients required assessment.
Observational (n=87)
No
Absolute Event Rate: 90.9% vs 53.9%
p-value: p=0.020
In ambulatory HFrEF patients, pathological hemodynamic responses to orthostatic stress are common, predominantly initial orthostatic hypotension and delayed BP recovery, and are associated with office SBP >140 mmHg but not with symptoms of orthostatic intolerance.
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Variable orthostatic BP responses in HFrEF outpatients may flag intolerance; leaves open whether AST monitoring guides therapy or risk stratification.
Fedorova et al. (2022) conducted an observational in Heart failure with reduced ejection fraction (n=87). Office systolic blood pressure >140 mm Hg vs. Office systolic blood pressure ≤140 mm Hg was evaluated on Pathological hemodynamic response to orthostatic stress (p=0.020). In ambulatory patients with HFrEF, pathological hemodynamic responses to orthostatic stress were significantly more frequent in those with office systolic blood pressure >140 mm Hg compared to ≤140 mm Hg (90.9% vs 53.9%, p=0.020).
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