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May 1, 1997American Journal of HypertensionOpen Access

Does Orthostatic Testing Have Any Role in the Evaluation of the Young Subject With Mild Hypertension? An Insight From the HARVEST Study

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Why the study?

Does orthostatic testing identify a distinct hemodynamic and sympathetic profile in young subjects with mild hypertension?

Population

1029 young subjects with stage I mild hypertension

Comparison

Orthostatic testing vs Normoreactors

Design

Cross-sectional

Authors

OVOlga VrizCardiac Imaging

Discussion

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Implication

Orthostatic hyperreactivity may mark a sympathetic phenotype in young mild hypertensives; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

Does orthostatic testing identify a distinct hemodynamic and sympathetic profile in young subjects with mild hypertension?

P
Population
1029 young subjects with stage I mild hypertension
I
Intervention
Orthostatic testing (blood pressure measurement after 2 min of standing)
C
Comparator
Normoreactors (diastolic BP increase ≤11 mm Hg from lying to standing)
O
Outcome
24-h ambulatory blood pressure, urinary catecholamines, and echocardiographic hemodynamic parameterssurrogate

Orthostatic testing in young mild hypertensives identifies a hyperreactive phenotype characterized by higher ambulatory blood pressure and a hyperkinetic hemodynamic pattern driven by increased sympathetic tone.

Cite This Study

Olga Vriz (1997) studied this question.

synapsesocial.com/papers/6a70738735aa2c282ce1c57ehttps://doi.org/10.1016/s0895-7061(96)00489-x

Topics

Hypertension managementEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic Responses to Tilt and Beta-Adrenergic Blockade in Young Patients with Borderline Hypertension1970 · 65 citations
  2. 2Baroreflex control of muscle sympathetic nerve activity in borderline hypertension.1990 · 96 citations
  3. 3Hyperkinetic borderline hypertension in Tecumseh, Michigan1991 · 250 citations
  4. 4Accuracy of the SpaceLabs 90207 determined by the British Hypertension Society Protocol1991 · 453 citations
  5. 5Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.1978 · 7,475 citations