Key result
Female sex linked to ~2.1 mL/kg/min lower peak exercise oxygen uptake than males in HF.
Why the study?
Are there sex-based differences in peak oxygen uptake among individuals with heart failure?
Meta-Analysis
Are there sex-based differences in peak oxygen uptake among individuals with heart failure?
Answers are grounded in this paper and cite their sources.
Females with heart failure have significantly lower peak exercise oxygen uptake compared to males, highlighting the need for sex-specific therapeutic approaches.
This meta-analysis revealed that peak exercise oxygen uptake is 2.1 mL/kg/min lower in females with heart failure compared with males, which may be due to having a lower peak cardiac output and arterial-venous O2 content difference. These findings highlight the importance of developing sex-specific therapeutic approaches to better address the added physiological challenges faced by females with heart failure to improve cardiovascular and skeletal muscle health outcomes.
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Skow et al. (2025) conducted a meta-analysis in Heart failure. Female sex vs. Male sex was evaluated on Peak exercise oxygen uptake (MD -2.1 mL/kg/min). Female sex is associated with a 2.1 mL/kg/min lower peak exercise oxygen uptake compared with males among individuals with heart failure.
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