Key result
Age, gender, and weight explain ~45% of peak oxygen uptake variance in severe CHF.
Why the study?
The influence of anthropometric and demographic characteristics on peak oxygen uptake in severe chronic heart failure patients had not been studied despite its prognostic importance.
Do age, gender, and body size influence peak oxygen uptake in patients with severe chronic heart failure?
Cross-Sectional (n=122)
Do age, gender, and body size influence peak oxygen uptake in patients with severe chronic heart failure?
Effect estimate: R2 0.45
p-value: p=<0.001
Peak oxygen uptake in severe chronic heart failure is independently influenced by weight, age, and gender, similar to healthy subjects, which should be considered when using it for prognostic purposes.
Consider age, gender, and weight when interpreting peak VO2 for prognosis in severe HF; extends healthy-subject observations but remains hypothesis-generating.
Anthropometric and demographic characteristics are important determinants of exercise performance in healthy subjects, but their influence has not yet been studied in severe chronic heart failure, although peak oxygen uptake is frequently assessed in such patients for prognostic purposes. The aim of the present analysis was to examine the association between peak oxygen uptake and age, gender, and measures of body size in patients with severe chronic heart failure. We selected 122 (99 male) adult heart transplant candidates who were able to perform a bicycle ergometer test with respiratory gas analysis until voluntary fatigue. Peak oxygen uptake was higher in male than in female patients, both before and after adjustment for weight. In single regression analysis on the total study population, peak oxygen uptake was positively related to weight and to height, but inversely to age (r = 0.59 (P < 0.001), 0.42 (P < 0.001), and -0.33 (P < 0.001), respectively). Multiple stepwise regression analysis identified weight (P < 0.001), age (P < 0.001), and gender (P < 0.01) as independent determinants of peak oxygen uptake (cumulative R2 = 0.45). Similar to the findings in healthy subjects, peak oxygen uptake of patients with severe chronic heart failure is influenced by anthropometric and demographic characteristics.
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Pardaens et al. (1997) conducted a cross-sectional in severe chronic heart failure (n=122). Age, gender, and body size was evaluated on peak oxygen uptake (R2 0.45, p=<0.001). Age, gender, and weight were identified as independent determinants of peak oxygen uptake in patients with severe chronic heart failure (cumulative R2 = 0.45).
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