Why the study?
Does intensified antihypertensive therapy reduce total mortality and the need for renal replacement therapy in hypertensive type 1 diabetic patients with overt nephropathy?
Population
91 hypertensive type 1 (insulin-dependent) diabetic patients with overt nephropathy
Comparison
Intensified antihypertensive therapy including… vs Routine antihypertensive therapy
Design
Cohort
Follow-up
5 years
Authors
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Intensified therapy was associated with fewer events in this cohort; leaves open whether it improves outcomes in randomized settings.
Does intensified antihypertensive therapy reduce total mortality and the need for renal replacement therapy in hypertensive type 1 diabetic patients with overt nephropathy?
Intensified antihypertensive therapy targeting blood pressure below 140/90 mmHg significantly improves survival and reduces the need for renal replacement therapy in type 1 diabetic patients with overt nephropathy.
Sawicki et al. (1995) studied this question.
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