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October 1, 1999Journal of Hypertension

Effects of intensified antihypertensive treatment in diabetic nephropathy

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Why the study?

Does an intensified antihypertensive therapy programme reduce mortality in hypertensive type 1 diabetic patients with overt diabetic nephropathy?

Population

91 hypertensive type 1 diabetic patients with overt diabetic nephropathy

Comparison

Intensified antihypertensive therapy programme… vs Routine antihypertensive treatment as provided…

Design

Cohort

Follow-up

10 years

Authors

ATAnna K. TrochaDeutsches Diabetes-Zentrum e.V.CSClaudia SchmidtkeInterventional / Structural CardiologyUDUlrike DidjurgeitSt. Franziskus Hospital

Discussion

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Implication

Intensified therapy was associated with lower mortality in type 1 diabetic nephropathy; leaves open confirmation in randomized trials.

Structured PICO

Does an intensified antihypertensive therapy programme reduce mortality in hypertensive type 1 diabetic patients with overt diabetic nephropathy?

P
Population
91 hypertensive type 1 diabetic patients with overt diabetic nephropathy
I
Intervention
Intensified antihypertensive therapy programme based on a structured teaching and treatment programme
C
Comparator
Routine antihypertensive treatment as provided by family physicians, consultants and local hospitals
O
Outcome
Death at 10 years follow-uphard clinical

Intensified antihypertensive therapy significantly reduces long-term mortality, dialysis, blindness, and amputation in patients with type 1 diabetes and overt nephropathy.

Cite This Study

Trocha et al. (1999) studied this question.

synapsesocial.com/papers/6a72f71b3347cc31859a2d53https://doi.org/10.1097/00004872-199917100-00019

Topics

Hypertension management
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Also Consider

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  1. 1How can we best prolong life? Benefits of coronary risk factor reduction in non-diabetic and diabetic subjects.1993 · 132 citations
  2. 2Accurate Estimation of Glomerular Filtration Rate in Diabetic Nephropathy From Age, Body Weight, and Serum Creatinine1992 · 59 citations