Key result
The ACE DD genotype was independently associated with higher 24-hour systolic and diastolic blood pressure, central systolic blood pressure, and central augmentation index in untreated hypertension.
Why the study?
Are renin-angiotensin system polymorphisms associated with ambulatory and central blood pressure in untreated Chinese patients with hypertension?
Cross-Sectional (n=471)
Are renin-angiotensin system polymorphisms associated with ambulatory and central blood pressure in untreated Chinese patients with hypertension?
The ACE I/D polymorphism (DD genotype) is independently associated with higher ambulatory and central blood pressure in untreated Chinese hypertensive patients.
Answers are grounded in this paper and cite their sources.
May identify higher-risk untreated hypertensives via ACE genotyping; extends prior associations to ambulatory and central BP but remains hypothesis-generating.
This study was conducted to explore whether the renin C-5312T, angiotensin II type 1 receptor A1166C, and angiotensin-converting enzyme I/D polymorphisms were associated with ambulatory blood pressure (BP) and central hemodynamics in an untreated hypertensive population. A total of 471 participants with no previous treatment for raised BP were eligible for the study. Ambulatory and central BP were measured. DD carriers had the highest daytime systolic/diastolic BP, nighttime systolic BP, 24-hour systolic BP, and 24-hour diastolic BP values, whereas carriers of DD had higher central systolic BP and augmentation index compared with those with the II genotype. Multivariate regression analysis demonstrated that DD genotype was independently associated with 24-hour systolic BP, 24-hour diastolic BP, central systolic BP, and central augmentation index. There was an independent association of the angiotensin-converting enzyme polymorphism with central and ambulatory BP in Chinese patients with hypertension.
No takes yet. Share an insight, caveat, or question.
Han et al. (2017) conducted a cross-sectional in Hypertension (n=471). Renin-angiotensin system polymorphisms (ACE DD genotype) vs. II genotype was evaluated on Ambulatory blood pressure and central hemodynamics. The ACE DD genotype was independently associated with higher 24-hour systolic and diastolic blood pressure, central systolic blood pressure, and central augmentation index in untreated hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: