What question did this study set out to answer?

This research aims to investigate how mechanical strain and extracellular matrix proteins influence the growth activity triggered by angiotensin II in vascular smooth muscle cells.

December 1, 1993Journal of Clinical InvestigationOpen Access

Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.

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Authors

KSKrishnankutty SudhirInterventional / Structural Cardiology EWEmily WilsonUniversity of Nebraska–Lincoln KCKanu ChatterjeeUniversity of Iowa

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Implication

Randomized trial explores mechanical strain and collagen impacts on angiogenic factors in rat vascular smooth muscle cells, indicating significant interactions.

Key Points

This research aims to investigate how mechanical strain and extracellular matrix proteins influence the growth activity triggered by angiotensin II in vascular smooth muscle cells.
Cultured rat vascular smooth muscle cells exposed to angiotensin II and various extracellular matrices for 48 hours.
Measured [3H]thymidine incorporation as an indicator of DNA synthesis enhancement.
Employed neutralizing antibodies and blockers to assess contributions of PDGF AB and other factors.
Angiotensin II increased DNA synthesis up to 53-fold when combined with collagen and mechanical strain.
Dup 753 significantly blocked the increase in DNA synthesis due to angiotensin II.
The interaction between angiotensin II and mechanical strain was mediated by PDGF AB, as indicated by results from neutralizing antibodies.

Cite This Study

Sudhir et al. (1993) studied this question.

synapsesocial.com/papers/6a20a21e01bc09701ff36f10 https://doi.org/10.1172/jci116923

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Implication

Randomized trial explores mechanical strain and collagen impacts on angiogenic factors in rat vascular smooth muscle cells, indicating significant interactions.

Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.

Discussion

Member takes

Implication

Key Points

Cite This Study

Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.

Discussion

Member takes

Implication

Key Points

Cite This Study

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