Key result
Left atrial appendage occlusion presents a potential alternative to warfarin for stroke prophylaxis in patients with severe aortic stenosis and atrial fibrillation undergoing transcatheter aortic valve replacement, particularly for those with increased bleeding risk.
Why the study?
Does left atrial appendage occlusion prevent stroke compared to warfarin in patients with severe aortic stenosis and atrial fibrillation undergoing TAVR?
Does left atrial appendage occlusion prevent stroke compared to warfarin in patients with severe aortic stenosis and atrial fibrillation undergoing TAVR?
This review discusses the potential benefit of left atrial appendage occlusion as an alternative to warfarin for stroke prophylaxis in patients with atrial fibrillation undergoing TAVR.
Many patients have now been able to receive transcatheter aortic valve replacement (TAVR) therapy for severe aortic stenosis. These patients have atrial fibrillation and are placed on warfarin for stroke prophylaxis. The opportunity for treatment with left atrial appendage occlusion (LAAO) in place of warfarin for this population exists, especially for those with increased bleeding risk. This paper discusses the prevalence and aetiology of stroke in patients presenting for TAVR (with a focus on the risk from chronic and acute atrial fibrillation) and also the benefit of LAAO closure in this population.
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Sameer Gafoor (2011) conducted a review in Severe aortic stenosis and atrial fibrillation. Left atrial appendage occlusion (LAAO) vs. Warfarin or other anticoagulants was evaluated. Left atrial appendage occlusion presents a potential alternative to warfarin for stroke prophylaxis in patients with severe aortic stenosis and atrial fibrillation undergoing transcatheter aortic valve replacement, particularly for those with increased bleeding risk.
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