Why the study?
Does left atrial appendage occlusion prevent stroke and reduce bleeding risk compared to warfarin in patients with atrial fibrillation undergoing TAVR?
Does left atrial appendage occlusion prevent stroke and reduce bleeding risk compared to warfarin in patients with atrial fibrillation undergoing TAVR?
This review highlights the potential opportunity for combining left atrial appendage occlusion with TAVR in patients with atrial fibrillation and high bleeding risk as an alternative to warfarin.
Many patients have now been able to receive transcatheter aortic valve replacement (TAVR) therapy for severe aortic stenosis. These patients have atrial fibrillation and are placed on warfarin for stroke prophylaxis. The opportunity for treatment with left atrial appendage occlusion (LAAO) in place of warfarin for this population exists, especially for those with increased bleeding risk. This paper discusses the prevalence and aetiology of stroke in patients presenting for TAVR (with a focus on the risk from chronic and acute atrial fibrillation) and also the benefit of LAAO closure in this population.
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Sameer Gafoor (2011) studied this question.
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