Key result
Implantation of the Amplatzer Cardiac Plug in 10 canines achieved 100% successful placement and complete left atrial appendage occlusion without embolization or device thrombus.
Why the study?
Does the Amplatzer Cardiac Plug safely and effectively occlude the left atrial appendage in a canine model?
Population
10 canines (animal model)
Design
Preclinical
Follow-up
up to approximately 90 days
Authors
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Supports proceeding to human trials; leaves open clinical safety and efficacy.
Does the Amplatzer Cardiac Plug safely and effectively occlude the left atrial appendage in a canine model?
The Amplatzer Cardiac Plug demonstrated safety and feasibility for transcatheter left atrial appendage occlusion in a canine model, supporting the initiation of human trials.
John L. Bass (2010) studied Left atrial appendage occlusion (n=10). Amplatzer Cardiac Plug was evaluated on Feasibility and efficacy of implanting the device (complete occlusion, thrombus formation, complications). Implantation of the Amplatzer Cardiac Plug in 10 canines achieved 100% successful placement and complete left atrial appendage occlusion without embolization or device thrombus.
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