Percutaneous Left Atrial Appendage Occlusion (PLAATO) for Preventing Cardioembolism
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Implication
Feasibility confirmed in canine AF model; leaves open translation to human stroke prevention trials.
Key Points
- This research aimed to evaluate the safety and feasibility of the PLAATO device for left atrial appendage occlusion in dogs.
- 25 dogs received a PLAATO implant through a 12F transseptal catheter.
- LAA sealing was confirmed using intracardiac echocardiography and contrast fluoroscopy.
- Follow-up assessments were conducted for 2 days to 6 months post-implantation.
- LAA was successfully occluded in all 25 cases.
- No mobile thrombi were associated with implantation and healing was 90% at 1 month, complete by 3 months.
- Light microscopy showed no emboli or infarcts in vital organs like the brain, kidney, and spleen.
Cite This Study
Nakai et al. (2002) studied this question.