Key result
AT2R +1675 A-allele carriers had greater left ventricular mass than G-allele carriers, and only G-allele carriers displayed a modulating effect of salt intake on left ventricular mass.
Why the study?
Does AT2R gene variation and salt intake impact left ventricular mass in subjects with normal or mildly elevated blood pressure?
Observational (n=205)
Does AT2R gene variation and salt intake impact left ventricular mass in subjects with normal or mildly elevated blood pressure?
Answers are grounded in this paper and cite their sources.
Left ventricular mass is influenced by AT2R polymorphisms, and G-allele carriers appear particularly susceptible to the modifying effect of increased salt intake on LVM.
Objectives In patients with hypertension left ventricular hypertrophy (LVH) is associated with genetic variations of the angiotensin type 2 receptor (AT2R). Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM). Methods and results In 205 subjects with normal or mildly elevated blood pressure, we assessed sodium intake and left ventricular structure and function by echocardiography. Intronic +1675 G/A polymorphism of the AT2R gene was investigated. A-allele carriers had a greater LVM (P = 0.049) than G-allele carriers. Independent of diet, septal wall thickness was higher in A-allele carriers (P = 0.001). Fractional fibre shortening was greater in A-allele carriers (P = 0.034), and the velocity of circumferential fibre shortening tended to be greater in A-allele carriers (P = 0.057). When the two groups were stratified according to their salt intake, only G-allele carriers displayed a modulating effect of salt intake on LVM. Covariance analysis revealed that there was a trend towards a modulating effect of salt intake on LVM, even after taking blood pressure into account (P = 0.054). Conclusion Our data clearly support the notion that LVM is influenced by AT2R polymorphisms. Furthermore, G-allele carriers in particular appear to be susceptible to a modifying effect of increased salt intake on LVM.
No takes yet. Share an insight, caveat, or question.
Ott et al. (2007) conducted an observational in normal or mildly elevated blood pressure (n=205). AT2R +1675 G/A polymorphism and sodium intake vs. G-allele carriers was evaluated on Left ventricular mass (LVM) (p=0.049). AT2R +1675 A-allele carriers had greater left ventricular mass than G-allele carriers, and only G-allele carriers displayed a modulating effect of salt intake on left ventricular mass.
Synapse has enriched 10 related papers. Consider them for comparative context: