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December 9, 2013Journal of Cardiovascular Electrophysiology

The Use of Signal Analyses of Ventricular Tachycardia Electrograms to Predict the Response of Antitachycardia Pacing in Patients with Implantable Cardioverter‐Defibrillators

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Key result

A lesser ventricular beat-to-beat morphologic variation in ICD recordings predicted successful antitachycardia pacing with an AUC of 0.769 (P<0.0001).

Why the study?

Does signal analysis of ventricular tachycardia electrograms predict the response to antitachycardia pacing in patients with ICDs?

Population

20 patients with implantable cardioverter-defibrillators who experienced 113 ventricular tachycardia…

Design

Cohort

Authors

TTTa‐Chuan TuanElectrophysiologyMLMen‐Tzung LoElectrophysiologyYLYenn‐Jiang LinElectrophysiology

Discussion

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Implication

Morphologic variation analysis on ICD electrograms may aid ATP success prediction in VT; hypothesis-generating and requires validation in prospective trials.

Study Design

Type

Observational (n=20)

Structured PICO

Does signal analysis of ventricular tachycardia electrograms predict the response to antitachycardia pacing in patients with ICDs?

P
Population
20 patients with implantable cardioverter-defibrillators who experienced 113 ventricular tachycardia episodes treated with antitachycardia pacing or shock.
E
Exposure
Signal analysis of ventricular tachycardia electrograms (EGMs), specifically evaluating beat-to-beat morphologic variation (divergence)
O
Outcome
Effectiveness/success of antitachycardia pacing (ATP) therapy

Main Result

Effect estimate: AUC 0.769

p-value: p=<0.0001

Lesser beat-to-beat morphologic variation in ventricular tachycardia electrograms predicts a higher probability of successful antitachycardia pacing in ICD patients.

Cite This Study

Tuan et al. (2013) conducted an observational in Ventricular tachycardia in patients with implantable cardioverter-defibrillators (n=20). Ventricular electrogram beat-to-beat morphologic variation (divergence) was evaluated on Successful antitachycardia pacing (ATP) therapy (AUC 0.769, p=<0.0001). A lesser ventricular beat-to-beat morphologic variation in ICD recordings predicted successful antitachycardia pacing with an AUC of 0.769 (P<0.0001).

synapsesocial.com/papers/6a20a6428b0daa6b96cd2ff5https://doi.org/10.1111/jce.12340
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphology of Far‐Field Electrograms and Antitachycardia Pacing Effectiveness Among Fast Ventricular Tachycardias Occurring in ICD Patients: A Multicenter Study2013 · 12 citations
  2. 2Local Activation Time Derived from Stored EGM is Associated with Failure of Antitachycardia Pacing in Patients with Implantable Defibrillator2009 · 2 citations
  3. 3Programming Antitachycardia Pacing for Primary Prevention in Patients With Implantable Cardioverter Defibrillators: Results From the PROVE Trial2010 · 50 citations
  4. 4The Magnitude of Sinus Cycle Length Change During Ventricular Tachycardia is Predictive of Successful Antitachycardia Pacing2006 · 7 citations
  5. 5Interactions Between Paced Wavefronts and Monomorphic Ventricular Tachycardia: Implications for Antitachycardia Pacing2006 · 11 citations