Why the study?
What is the relationship between serum digoxin concentration and inotropic response across different dosing patterns?
Population
12 normal male volunteers (data from a previous study)
Design
Other
Authors
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May support lower digoxin targets to limit toxicity risk; leaves open prospective validation of nonlinear response.
What is the relationship between serum digoxin concentration and inotropic response across different dosing patterns?
The nonlinear relationship between serum digoxin concentration and inotropic response suggests that higher doses yield diminishing returns in efficacy, which has important implications for avoiding digoxin toxicity.
Kolibash et al. (1989) studied this question.
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