Why the study?
Does pharmacokinetic prediction accurately estimate serum digoxin concentrations in elderly nursing home residents?
Population
19 elderly residents of a nursing home
Comparison
Pharmacokinetic prediction of serum digoxin… vs Measured steady-state serum digoxin concentration
Design
Cross-sectional
Authors
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Calculated digoxin levels underestimated measured values in 33% of elderly residents; leaves open pharmacokinetic model accuracy and requires prospective validation.
Does pharmacokinetic prediction accurately estimate serum digoxin concentrations in elderly nursing home residents?
Pharmacokinetic models for predicting serum digoxin concentrations in the elderly show significant correlation but frequently underestimate actual levels, highlighting the need for improved predictive models.
Arshag D. Mooradian (1987) studied this question.
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