Why the study?
Does old age alter the pharmacokinetics of single-dose digoxin compared to young patients?
Population
13 patients (6 young and 7 elderly)
Comparison
Single-dose digoxin vs Young patients
Design
Cohort
Authors
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May support age-adjusted digoxin dosing; leaves open prospective outcome validation in elderly.
Does old age alter the pharmacokinetics of single-dose digoxin compared to young patients?
Elderly patients exhibit reduced plasma clearance and a longer half-life of digoxin, highlighting the pharmacokinetic basis for age-related dose adjustments.
Cusack et al. (1979) studied this question.
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