Key result
Aging leads to changes in body composition, decreased renal function, and reduced volume of distribution, which prolong the plasma elimination of digoxin and increase the risk of toxicity in older patients.
Population
Older people
Design
Review
Authors
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Supports cautious individualized digoxin dosing in older patients; leaves open prospective validation of monitoring strategies.
Due to age-related pharmacokinetic changes and a narrow therapeutic index, digoxin dosing in the elderly requires careful individualization, typically starting low and escalating slowly with close monitoring.
Geoffrey Currie (2011) conducted a review in Heart failure and arrhythmia. Digoxin was evaluated. Aging leads to changes in body composition, decreased renal function, and reduced volume of distribution, which prolong the plasma elimination of digoxin and increase the risk of toxicity in older patients.
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