Why the study?
Do serum and salivary digoxin levels correlate with ECG PTQ-changes in healthy volunteers?
Population
4 healthy volunteers
Comparison
Increasing oral doses of digoxin over a 6-7 week… vs 1 week of baseline observations
Design
Case_series
Follow-up
6-7 weeks
Authors
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May support non-invasive PTQ and salivary monitoring of digoxin effects; leaves open validation in patients.
Do serum and salivary digoxin levels correlate with ECG PTQ-changes in healthy volunteers?
PTQ-changes and serial salivary digoxin levels may serve as useful non-invasive indices for monitoring digoxin pharmacodynamics and cardiac glycoside effects.
Joubert et al. (1976) studied this question.
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