Why the study?
Does digoxin treatment correlate with quantitative electrocardiographic changes in elderly female patients with mild congestive cardiac failure?
Does digoxin treatment correlate with quantitative electrocardiographic changes in elderly female patients with mild congestive cardiac failure?
Quantitative ECG changes, particularly T-wave amplitude, correlate significantly with serum digoxin concentrations and revert to baseline upon discontinuation.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for T-wave amplitude tracking digoxin effect in elderly HF; larger studies required before any monitoring role.
Four elderly female patients in sinus rhythm and with mild congestive cardiac failure were treated with digoxin and studied over a 6-month period. There were significant linear correlations between serum digoxin concentrations and several quantitative electrocardiographic (ECG) parameters. T-wave amplitude was the most important ECG variable. ECG changes reverted to baseline values when digoxin was discontinued. These findings suggest that quantitative ECG changes are potentially useful in clinical and research situations involving digitalis glycosides.
No takes yet. Share an insight, caveat, or question.
Joubert et al. (1975) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: