December 1, 1991Proceedings of the National Academy of SciencesOpen Access

Rapid dissociation and reassociation of actomyosin cross-bridges during force generation: a newly observed facet of cross-bridge action in muscle.

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Population

Skinned fibers of the rabbit psoas muscle

Design

Preclinical

Authors

BBBernhard BrennerFlorida State University

Discussion

Member takes

Implication

May advance sarcomere dynamics models; leaves open translation to human cardiac therapies.

Structured PICO

Population

Skinned fibers of the rabbit psoas muscle

Intervention

Stretches and releases at physiological ionic strength and low experimental temperature (5 degrees C)

Outcome

Force response and fiber stiffness vs. speed of imposed length changessurrogate

Rapidly reversible actin interaction of cross-bridges in force-generating states provides a mechanism for rapid detachment during high-speed shortening without requiring completion of the ATP-hydrolysis cycle.

Cite This Study

Bernhard Brenner (1991) studied this question.

synapsesocial.com/papers/6a20a8369ca8a48788f36f1e https://doi.org/10.1073/pnas.88.23.10490

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