Highlights the role of the endothelium as a mechanotransducer of flow-related forces, particularly shear stresses, in vascular physiology and atherosclerosis.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications; leaves open targeted endothelial therapies for atherosclerosis.
Endothelial cells lining the circulation are continuously subjected to hemodynamic forces. Because flow is known to influence constriction and relaxation of small arteries and is implicated in the localization of athherosclerotic lesions in large arteries, the role of the endothelium as a "mechanotransducer" of flow-related forces, particularly shear stresses, is of great interest.
No takes yet. Share an insight, caveat, or question.
P. A. Davies (1989) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: