January 1, 2000Journal of Biological ChemistryOpen Access

X-ray Structures of the Dictyostelium discoideumMyosin Motor Domain with Six Non-nucleotide Analogs

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Population

Truncated myosin head from Dictyostelium discoideum myosin II

Comparison

Complexation with six non-nucleotide analogs vs S1dC.ADP.BeF(x) structure

Design

Preclinical

Authors

AGAndrew M. GulickJacobs (United States)CBCary B. BauerBruker (United States)JTJames B. ThodenUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

May inform substrate design via water interactions; leaves open functional validation in human cardiovascular models.

Structured PICO

Population

Truncated myosin head from Dictyostelium discoideum myosin II

Intervention

Complexation with six non-nucleotide analogs (dinitrophenylaminoethyl-, dinitrophenylaminopropyl-, o-nitrophenylaminoethyl-, m-nitrophenylaminoethyl-, p-nitrophenylaminoethyl-, and o-nitrophenyl-N-methyl-aminoethyl-diphosphate.beryllium fluoride)

Comparator

S1dC.ADP.BeF(x) structure

Outcome

Three-dimensional structures determined to better than 2.3-A resolutionsurrogate

The ability of a substrate to sustain tension and generate movement correlates with a well-defined interaction with the active site water structure.

Cite This Study

Gulick et al. (2000) studied this question.

synapsesocial.com/papers/6a20aa717cf5d95c4e72e259 https://doi.org/10.1074/jbc.275.1.398

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X-ray Structures of the Dictyostelium discoideumMyosin Motor Domain with Six Non-nucleotide Analogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

X-ray Structures of the Dictyostelium discoideumMyosin Motor Domain with Six Non-nucleotide Analogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider