The E459V and E476K mutations in Dictyostelium discoideum myosin II dramatically reduce the ATP hydrolysis rate, creating long-lived myosin-ATP states that serve as ideal tools for elucidating structural features of the myosin ATPase cycle.
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Provides tools for myosin ATPase structural studies in models; leaves open translation to human cardiac myosin function.
Friedman et al. (1998) studied this question.
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