January 1, 1989CirculationOpen Access

Severe impairment of coronary reserve during rejection in patients with orthotopic heart transplant.

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Why the study?

Does dipyridamole-induced coronary vasodilation reveal impaired coronary reserve in heart transplant patients with histologic signs of rejection compared to those without rejection?

Population

12 patients after orthotopic heart transplantation with normal coronary arteriograms, treated with…

Comparison

Intravenous dipyridamole vs Comparison between patients with histologic…

Design

Cross-sectional

Authors

ANA NitenbergAssistance Publique – Hôpitaux de Paris OTOscar TavolaroHôpital Privé Jacques Cartier DLD LoisanceAcadémie Nationale de Médecine

Discussion

Member takes

Implication

Basal coronary hemodynamics do not distinguish rejection; leaves open whether dipyridamole testing detects impaired reserve in transplants.

Structured PICO

Does dipyridamole-induced coronary vasodilation reveal impaired coronary reserve in heart transplant patients with histologic signs of rejection compared to those without rejection?

Population

12 patients after orthotopic heart transplantation with normal coronary arteriograms, treated with cyclosporine and prednisone (some with azathioprine). 7 patients had no sign of rejection on endomyocardial biopsy (group 1) and 5 patients had histologic signs of rejection (group 2).

Intervention

Intravenous dipyridamole (0.18 mg/kg/min over 4 minutes)

Comparator

Comparison between patients with histologic signs of rejection (group 2) and those without signs of rejection (group 1)

Outcome

Coronary sinus blood flow and coronary resistance alterations after dipyridamole-induced coronary vasodilationsurrogate

In heart transplant patients, basal coronary hemodynamics are similar regardless of rejection status, though the study title suggests severe impairment of coronary reserve during rejection upon vasodilation.

Cite This Study

Nitenberg et al. (1989) studied this question.

synapsesocial.com/papers/6a20aab8b447e61ff57bd551 https://doi.org/10.1161/01.cir.79.1.59

Topics

Heart transplantation

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Implication

Basal coronary hemodynamics do not distinguish rejection; leaves open whether dipyridamole testing detects impaired reserve in transplants.

Severe impairment of coronary reserve during rejection in patients with orthotopic heart transplant.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Severe impairment of coronary reserve during rejection in patients with orthotopic heart transplant.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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