Key result
Eosinophilic myocarditis was identified in 7.4% of explanted hearts, but 8-year postoperative survival was similar between patients with and without the condition (50% vs 54%, p=0.34).
Why the study?
What is the prevalence, potential cause, and prognostic impact of eosinophilic myocarditis in patients awaiting heart transplantation?
Population
190 consecutive patients who underwent heart transplantation at a large university-affiliated hospital
Comparison
Evaluation of explanted hearts for eosinophilic… vs Patients without eosinophilic myocarditis on…
Design
Cohort
Follow-up
8 years
Authors
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Eosinophilic myocarditis does not worsen post-transplant survival; leaves open its etiology and preoperative management in advanced HF.
Observational (n=190)
No
What is the prevalence, potential cause, and prognostic impact of eosinophilic myocarditis in patients awaiting heart transplantation?
Absolute Event Rate: 50% vs 54%
p-value: p=0.34
Eosinophilic myocarditis is present in approximately 7% of explanted hearts, likely related to hypersensitivity to preoperative medications such as inotropes, but it does not adversely affect long-term post-transplant survival.
Takkenberg et al. (2004) conducted an observational in Patients awaiting heart transplantation (n=190). Eosinophilic myocarditis vs. No eosinophilic myocarditis was evaluated on Postoperative survival at 8 years (p=0.34). Eosinophilic myocarditis was identified in 7.4% of explanted hearts, but 8-year postoperative survival was similar between patients with and without the condition (50% vs 54%, p=0.34).
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