What is the clinical evidence from this study?

Study design: Cohort. Population: Acute eosinophilic myocarditis (n=156). Intervention: Acute eosinophilic myocarditis. Primary outcome: Death or heart transplantation (HTx) at 3 years.

What does this research mean for the field?

Acute eosinophilic myocarditis frequently presents without peripheral eosinophilia and carries high mortality, with increased age, decreased admission LVEF, and lack of immunosuppressive therapy acting as independent predictors of death or heart transplantation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To characterize the clinical presentation, underlying etiologies, treatment strategies, and clinical outcomes of histologically confirmed acute eosinophilic myocarditis.

September 15, 2026European Heart Journal Supplements

Eosinophilic Myocarditis International Registry

View Full Paper

Ask AI

Bookmark

Key result

Acute eosinophilic myocarditis is linked to a ~24% 3-year rate of death or HTx.

n=156

Population

156 patients with histologically confirmed acute eosinophilic myocarditis, median age 48, 67% male.

Design

Cohort

Follow-up

up to 3 years

Authors

MPM PalazziniJohns Hopkins University JLJ LehtonenJohns Hopkins University LPL PotenaJohns Hopkins University

Discussion

Member takes

Implication

Acute EM carries 15-24% short-term mortality despite immunosuppression; extends case-series data on presentation and predictors but leaves optimal management open.

Key Points

To characterize the clinical presentation, underlying etiologies, treatment strategies, and clinical outcomes of histologically confirmed acute eosinophilic myocarditis.
International retrospective cohort study across 53 centers on five continents between 1992 and 2023.
Analyzed 156 patients with histologically confirmed acute eosinophilic myocarditis and symptom duration of 30 days or less.
Peripheral eosinophilia was present in only 57% of patients, and median left ventricular ejection fraction at presentation was 32% (IQR 25–48%).
In-hospital death or heart transplantation occurred in 15% (n=23), with 1- and 3-year cumulative event rates of 19% and 24%, respectively.
Increased age, lower baseline left ventricular ejection fraction, and lack of in-hospital immunosuppressive therapy were independent predictors of death or heart transplantation.

Study Design

Type

Cohort (n=156)

Multicenter

Yes

Structured PICO

Population

156 patients with histologically confirmed acute eosinophilic myocarditis across 53 centers globally, followed for up to 3 years.

Outcome

In-hospital death or heart transplantation (HTx), and 1- and 3-year cumulative rates of death or HTxhard clinical

Acute eosinophilic myocarditis carries a high mortality and frequently presents without peripheral eosinophilia, emphasizing the critical role of endomyocardial biopsy for diagnosis.

Cite This Study

Palazzini et al. (2026) conducted a cohort in Acute eosinophilic myocarditis (n=156). Acute eosinophilic myocarditis was evaluated on Death or heart transplantation (HTx) at 3 years. Acute eosinophilic myocarditis was associated with high mortality, with in-hospital death or heart transplantation occurring in 15% of patients and a 3-year cumulative rate of 24%.

synapsesocial.com/papers/6aa9016aeed42882c1fc18a0 https://doi.org/10.1093/eurheartjsupp/suag058.401

Topics

Myocarditis Heart transplantation

View Full Paper

Ask AI

Bookmark

Implication

Acute EM carries 15-24% short-term mortality despite immunosuppression; extends case-series data on presentation and predictors but leaves optimal management open.

Eosinophilic Myocarditis International Registry

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Eosinophilic Myocarditis International Registry

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider