Key result
Lithium overdose and chronic therapy are associated with a wide range of cardiovascular complications, including cardiac arrhythmias and interstitial myocarditis.
Why the study?
Does chronic lithium therapy cause cardiovascular complications such as sinus node dysfunction?
Case Report
Does chronic lithium therapy cause cardiovascular complications such as sinus node dysfunction?
Lithium therapy, particularly in overdose, can lead to significant cardiovascular complications including sinus node dysfunction and interstitial myocarditis.
Supports cardiac monitoring in lithium users; leaves open causality of chronic therapy.
Lithium is derived from the Greek word "lithia" which means "stone." Since its discovery by the Swedish chemist Arfedsson in the year 1817, it has been used for treatment of gout, hypertension, uremia, and rheumatism. Currently, lithium is the treatment of choice for the long-term control of mania and to prevent relapse in bipolar disorder. It has a narrow therapeutic index (0.6-1.2 mEq/L). Lithium overdose has been associated with a wide range of cardiovascular complications including cardiac arrhythmias and interstitial myocarditis. We present a review of published cases relevant to lithium-related cardiotoxicity.
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Talati et al. (2009) conducted a case report in Lithium-related cardiotoxicity. Chronic Lithium Therapy was evaluated on Cardiovascular complications including cardiac arrhythmias and interstitial myocarditis. Lithium overdose and chronic therapy are associated with a wide range of cardiovascular complications, including cardiac arrhythmias and interstitial myocarditis.
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