Key result
Oral captopril blunts resting blood pressure and acute stress-evoked cardiovascular responses in infarcted rats.
ACE inhibition with captopril normalizes exaggerated cardiovascular responses to acute stress in rats with post-infarct heart failure and chronic stress.
Captopril may blunt exaggerated stress responses in post-MI rat models; hypothesis-generating for stressed HF patients, with human trials required.
Previous studies showed that chronically stressed and myocardially infarcted rats respond with exaggerated cardiovascular responses to acute stress. The present experiments were designed to elucidate whether this effect can be abolished by treatment with the angiotensin converting enzyme (ACE) inhibitor captopril. Sprague Dawley rats were subjected either to sham surgery (Groups 1 and 2) or to myocardial infarction (Groups 3 and 4). The rats of Groups 2 and 4 were also exposed to mild chronic stressing. Four weeks after the operation, mean arterial blood pressure (MABP) and heart rate (HR) were measured under resting conditions and after application of acute stress. The cardiovascular responses to the acute stress were determined again 24 h after administration of captopril orally. Captopril significantly reduced resting MABP in each group. Before administration of captopril, the maximum increases in MABP evoked by the acute stressor in all (infarcted and sham-operated) chronically stressed rats and also in the infarcted nonchronically stressed rats were significantly greater than in the sham-operated rats not exposed to chronic stressing. These differences were abolished by captopril. The results suggest that ACE may improve tolerance of acute stress in heart failure and during chronic stressing.
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Cudnoch‐Jędrzejewska et al. (2014) studied Myocardial infarction and chronic stress (n=48). Captopril vs. Baseline (before captopril administration) and sham-operated nonchronically stressed rats was evaluated on Maximum increases in mean arterial blood pressure (MABP) evoked by acute stressor (p=<0.05). Oral administration of captopril significantly reduced resting arterial blood pressure and the pressor and tachycardic responses to acute stress in chronically stressed and infarcted rats.
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