Population
In vitro expression system using a complete cDNA copy of the poliovirus genome inserted into a bacteriophage…
Design
Preclinical
Authors
Loading...
These cleavage requirements warrant caution extrapolating to live-virus or therapeutic contexts; extends in vitro mapping but leaves open in vivo validation.
The study identifies specific sequence requirements for the in vitro cleavage of the poliovirus P1 precursor by 3C and 2A proteinases.
Ypma-Wong et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: