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September 21, 2017Alcoholism Clinical and Experimental Research

The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?

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Authors

MPMatthew B. PomrenzeTFTracy L. FetterlyDWDanny G. Winder

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Overview

Review analyzes the effectiveness of CRFR1 antagonists on alcohol craving in alcohol use disorder, suggesting implications for future research.

Key Points

  • This research assesses whether CRFR1 remains a viable target for treating alcohol use disorder after reviewing preclinical and human studies.
  • Examined pilot studies of CRFR1 antagonists in humans with alcohol use disorder.
  • Discussed findings from preclinical and human literature.
  • Analyzed the response to stress and alcohol craving linked to CRFR1.
  • Pilot studies failed to show significant effects of CRFR1 antagonists on stress-induced alcohol craving.
  • Preclinical studies suggest a strong link between CRFR1 and alcohol consumption behaviors.
  • Need for further investigation into the limitations of existing CRFR1 antagonist studies.

Cite This Study

Pomrenze et al. (2017) studied this question.

synapsesocial.com/papers/6a20ba59f9039b2a31e4e599https://doi.org/10.1111/acer.13507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons2025
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  3. 3Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis2025
  4. 4Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder2024 · 22 citations
  5. 5Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability2024 · 4 citations