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March 25, 2026eLifeOpen Access

Alcohol attenuates CRF-induced excitatory effects from the extended amygdala to dorsostriatal cholinergic interneurons

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Authors

AEAmanda EssohXXXuan XieHGHimanshu Gangal

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Overview

Reveals how alcohol affects excitatory signaling in the brain through corticotropin-releasing factor pathways, indicating new treatment targets.

Key Points

  • This research investigates how corticotropin-releasing factor (CRF) influences cholinergic interneurons (CINs) in the dorsal striatum and how alcohol alters this interaction.
  • Utilized both mice and rats for the experiment
  • Conducted monosynaptic and retrograde circuit tracing
  • Identified CRF-expressing neurons in the central amygdala and bed nucleus of the stria terminalis
  • Performed functional recordings of CIN excitability and acetylcholine release
  • Confirmed that CINs express CRF receptor 1 (CRFR1) and are connected to CRF + projections
  • Found that CRF enhances CIN excitability and increases acetylcholine release
  • Observed that acute alcohol exposure and withdrawal significantly reduce CRF's excitatory effects on CIN firing

Cite This Study

Essoh et al. (2026) studied this question.

synapsesocial.com/papers/69c37bc2b34aaaeb1a67e6c8https://doi.org/10.7554/elife.107145.3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons2025
  2. 2Inhibiting CRF Projections from the Central Amygdala to Lateral Hypothalamus and Amygdala Deletion of CRF Alters Binge-Like Ethanol Drinking in a Sex-Dependent Manner2024 · 1 citations
  3. 3Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder2024 · 22 citations
  4. 4Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice2025
  5. 5Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability2024 · 4 citations