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July 21, 2025Open Access

Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

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Authors

AEAmanda EssohHGHimanshu GangalZHZhenbo Huang

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Overview

Experiments show alcohol reduces CRF-induced changes in cholinergic interneurons in the dorsal striatum, indicating effects on reward signaling.

Key Points

  • Alcohol alters the excitatory influence of corticotropin-releasing factor on cholinergic interneurons.
  • Investigation utilized monosynaptic tracing to reveal connectivity between CRF neurons and striatal circuits.
  • Cholinergic interneurons were found to express CRF receptor 1, indicating sensitivity to CRF signaling.
  • Discovering the interaction between CRF and alcohol contributes to understanding stress effects on reward pathways.

Cite This Study

Essoh et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd529https://doi.org/10.7554/elife.107145.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alcohol attenuates CRF-induced excitatory effects from the extended amygdala to dorsostriatal cholinergic interneurons2026
  2. 2The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?2017 · 49 citations
  3. 3Inhibiting CRF Projections from the Central Amygdala to Lateral Hypothalamus and Amygdala Deletion of CRF Alters Binge-Like Ethanol Drinking in a Sex-Dependent Manner2024 · 1 citations
  4. 4Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder2024 · 22 citations
  5. 5Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability2024 · 4 citations