Key result
Polymorphisms in the ADAM33 gene were linked to an increased susceptibility to asthma and bronchial hyperresponsiveness, with associated alleles ranging in frequency from 20% to 95%.
Why the study?
Are polymorphisms in the ADAM33 gene associated with asthma and bronchial hyperresponsiveness?
Population
460 white affected sib-pair families from the United States and the United Kingdom with current asthma
Design
Other
Authors
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ADAM33 variants merit further mechanistic study in pediatric asthma; leaves open any role in risk stratification or management.
Case-Control (n=460)
Yes
Are polymorphisms in the ADAM33 gene associated with asthma and bronchial hyperresponsiveness?
Polymorphisms in the ADAM33 gene are linked to an increased susceptibility to asthma and bronchial hyperresponsiveness, potentially underlying lower airways dysfunction and remodeling.
Thatayatikom et al. (2003) conducted a case-control in Asthma and bronchial hyperresponsiveness (n=460). ADAM33 gene polymorphisms was evaluated on Asthma and bronchial hyperresponsiveness. Polymorphisms in the ADAM33 gene were linked to an increased susceptibility to asthma and bronchial hyperresponsiveness, with associated alleles ranging in frequency from 20% to 95%.
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