What question did this study set out to answer?

The aim is to establish the role of myoglobin in facilitating oxygen diffusion and maintaining cardiac muscle function in mammals.

September 1, 1986Cardiovascular Research

Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac muscle

View Full Paper

Ask AI

Bookmark

Why the study?

Does myoglobin-facilitated oxygen diffusion maintain the mechanical function of mammalian cardiac muscle?

Population

Isolated kitten papillary muscles (diameter ≤ 0.70 mm)

Comparison

Inactivation of myoglobin using 2 X 10 mol/L… vs Normal myoglobin function and recovery state

Design

Preclinical

Authors

EBElizabeth BraunlinUniversity of Minnesota GWGordon M. WahlerMidwestern University CSC. R. SwayzeLouisiana State University in Shreveport

Discussion

Member takes

Implication

Animal data link myoglobin to relaxation kinetics; leaves open relevance to human diastolic function or hypoxia.

Key Points

The aim is to establish the role of myoglobin in facilitating oxygen diffusion and maintaining cardiac muscle function in mammals.
Isolated kitten papillary muscles stimulated at 24 X min-1 under isometric conditions.
Experimental setup involved sodium nitrite to inactivate myoglobin and sodium iodoacetate for glycolytic blockade.
Bath oxygen levels adjusted to assess effects on relaxation rate under various oxygen conditions.
Inactivation of myoglobin led to a 22% decrease in maximal relaxation rate with blockade and 10% without blockade (p < 0.05).
Increased bath oxygen tension to 600 mm Hg reversed the depression in mechanical function.
Maximal rate of relaxation serves as a sensitive indicator of hypoxia.

Structured PICO

Does myoglobin-facilitated oxygen diffusion maintain the mechanical function of mammalian cardiac muscle?

Population

Isolated kitten papillary muscles (diameter ≤ 0.70 mm)

Intervention

Inactivation of myoglobin using 2 X 10(-3) mol/L sodium nitrite (with or without 10(-4) mol/L sodium iodoacetate for glycolytic blockade)

Comparator

Normal myoglobin function (prior to inactivation) and recovery state (increased bath oxygen tension to ~600 mm Hg)

Outcome

Maximal rate of relaxation (-dT/dtmax) under isometric conditionssurrogate

Myoglobin-facilitated oxygen diffusion is essential for maintaining the mechanical function of mammalian cardiac muscle, and the maximal rate of relaxation is a sensitive indicator of hypoxia.

Cite This Study

Braunlin et al. (1986) studied this question.

synapsesocial.com/papers/6a20bae99f43da0f9dab379a https://doi.org/10.1093/cvr/20.9.627

View Full Paper

Ask AI

Bookmark

Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider