Population
18 purpose-bred littermate dogs (aged 10-12 months)
Comparison
Exercise training for 8 weeks or left leg… vs Control group (no training or immobilization)
Design
Preclinical, 1 dog per litter allocated to each of three groups
Follow-up
8 weeks (training) or 3 weeks (immobilization)
Authors
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Immobilization-induced capillary adaptations fail to improve muscle O2 diffusing capacity; leaves open the role of diffusion distance in oxygen transport.
Increased capillary density and reduced diffusion distance after short-term immobilization does not improve muscle O2 diffusing capacity in heavily working skeletal muscle.
Hepple et al. (2000) studied this question.
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