April 1, 2000Acta Physiologica ScandinavicaOpen Access

Perfusion, diffusion and their heterogeneities limiting blood–tissue O2 transfer in muscle

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Population

Humans at maximum O2 uptake (based on literature data) and isolated/in situ muscles

Design

Review

Authors

JPJohannes PiiperMax Planck Institute of Experimental Medicine

Discussion

Member takes

Implication

Highlights context-specific O2 delivery needs in hypoxia; leaves open clinical validation of heterogeneity effects on efficiency.

Structured PICO

Population

Humans at maximum O2 uptake (based on literature data) and isolated/in situ muscles

Outcome

Relative roles of blood flow (perfusion) and diffusion in O2 supply to exercising musclesurrogate

Theoretical modeling demonstrates that muscle O2 supply is limited by both perfusion and diffusion, and that blood flow heterogeneity significantly impacts O2 transfer efficiency.

Limitations

The homogeneous model underestimates true diffusing capacity and overestimates diffusion limitation when heterogeneity is present.

Cite This Study

Johannes Piiper (2000) studied this question.

synapsesocial.com/papers/6a70464bac440176ef28ed0b https://doi.org/10.1046/j.1365-201x.2000.00711.x

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