Electronically monitored medication adherence predicts hospitalization in heart failure patients
Key result
Poor medication adherence and its interactions with other risk factors strongly predicted 6-month hospitalization in heart failure patients, yielding an excellent discrimination C-index of 0.83.
Why the study?
Does objectively measured medication adherence predict hospitalization within 6 months in adults with heart failure?
Population
Adults with heart failure
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
May enhance HF risk stratification; leaves open whether adherence interventions reduce hospitalizations.
Study Design
Type
Observational
Structured PICO
Does objectively measured medication adherence predict hospitalization within 6 months in adults with heart failure?
P
Population
Adults with heart failure followed for 6 months to assess predictors of hospitalization.
E
Exposure
Medication adherence objectively measured by the Medication Event Monitoring System
O
Outcome
Hospitalization within 6 monthshard clinical
Main Result
Effect estimate: C-index 0.83
Absolute Event Rate: 100% vs 9.7%
Objectively measured medication adherence is a strong predictor of 6-month hospitalization in heart failure patients, significantly improving risk prediction models.
Cite This Study
Riegel et al. (2013) conducted an observational in Heart failure. Poor medication adherence and interaction risk factors vs. No interaction risk factors was evaluated on Hospitalization within 6 months (C-index 0.83). Poor medication adherence and its interactions with other risk factors strongly predicted 6-month hospitalization in heart failure patients, yielding an excellent discrimination C-index of 0.83.