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March 1, 2003Diabetes CareOpen Access

Comparison of a Clinical Model, the Oral Glucose Tolerance Test, and Fasting Glucose for Prediction of Type 2 Diabetes Risk in Japanese Americans

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Authors

MMMarguerite J. McNeelyEBEdward J. BoykoDLDonna L. Leonetti

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Overview

Randomized trial compares diabetes prediction methods in Japanese Americans, showing varying effectiveness by age.

Key Points

  • To evaluate the effectiveness of a clinical model and glucose tests in predicting type 2 diabetes risk among Japanese Americans.
  • 465 nondiabetic Japanese Americans aged 34-75 years were studied at baseline and followed for 5-10 years.
  • Diabetes status was assessed using the 75-g oral glucose tolerance test and compared against a clinical model including various risk factors.
  • Receiver-operating characteristic (ROC) curves evaluated the predictive validity of the clinical model, fasting plasma glucose, and 2-h glucose.
  • For subjects aged ≤55 years, the clinical model had a ROC curve area of 0.896, which was better than FPG (0.776, P=0.008).
  • For older subjects, the 2-h glucose ROC area (0.792) was superior to the clinical model (0.599, P≤0.001).
  • At 10 years, no significant differences were observed in prediction accuracy among the clinical model, FPG, and 2-h glucose in either age group.

Cite This Study

McNeely et al. (2003) studied this question.

synapsesocial.com/papers/6a20cfdd67c00b242d13e78bhttps://doi.org/10.2337/diacare.26.3.758
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