Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function
Why the study?
Does antecedent hypoglycemia impair cardiovascular autonomic function in healthy subjects?
Population
20 healthy subjects (age 28 +/- 2 years; 10 men)
Comparison
Two 2-h hyperinsulinemic hypoglycemic clamps… vs Two 2-h hyperinsulinemic euglycemic clamps…
Design
Other
Follow-up
3 days per visit
Authors
Discussion
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Member takes
Implication
Antecedent hypoglycemia may blunt autonomic responses to hypotension; hypothesis-generating for cardiovascular risks in diabetes.
Structured PICO
Does antecedent hypoglycemia impair cardiovascular autonomic function in healthy subjects?
P
Population
20 healthy subjects (age 28 +/- 2 years; 10 men)
I
Intervention
Two 2-h hyperinsulinemic hypoglycemic (2.8 mmol/l) clamps performed in the morning and afternoon of day 2
C
Comparator
Two 2-h hyperinsulinemic euglycemic (5.0 mmol/l) clamps performed in the morning and afternoon of day 2
O
Outcome
Autonomic function (sympathetic, parasympathetic, and baroreflex function) measured on day 3surrogate
Antecedent hypoglycemia attenuates baroreflex sensitivity and sympathetic response to hypotensive stress in healthy subjects, raising concerns about the cardiovascular consequences of hypoglycemia in diabetes.
Cite This Study
Adler et al. (2008) studied this question.