Key result
Endothelial function and nitric oxide availability were inversely related to the severity of resistance artery remodelling, independently of the European Heart Score.
Why the study?
The relationship between resistance artery remodelling and endothelial function remains unknown.
Population
356 patients with small resistance artery remodelling measures from the Italian Society for Arterial Hypertension registry
Comparison
Endothelial function and NO availability vs cardiovascular risk factors (European Heart Score)
Design
Observational cohort study
Authors
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Hypothesis-generating for endothelial-targeted interventions in hypertension; longitudinal studies needed to assess causality.
Observational (n=356)
Endothelial dysfunction and reduced nitric oxide availability are associated with resistance artery remodelling independently of traditional cardiovascular risk factors.
Masi et al. (2019) conducted an observational in Cardiovascular risk (n=356). Endothelial dysfunction and nitric oxide availability deficit was evaluated on Severity of resistance artery remodelling (media-to-lumen ratio and media cross-sectional area). Endothelial function and nitric oxide availability were inversely related to the severity of resistance artery remodelling, independently of the European Heart Score.
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