Key result
Adult chicken breast muscle fibers expressing acidic TnT isoforms showed significantly increased sensitivity to Ca2+ of force and stiffness compared to fibers expressing solely basic TnT isoforms.
Effect estimate: shift of approximately 0.15 in pCa50
TnT isoforms differing in their NH2-terminal charge alter the sensitivity of the myofibrillar contractile apparatus to Ca2+, linking TnT isoform classes to striated muscle contractility.
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TnT isoform effects on Ca2+ sensitivity in avian muscle are hypothesis-generating; leaves open translation to mammalian striated muscle contractility.
Ogut et al. (1999) studied this question. Acidic TnT isoform expression (adult chicken breast muscle) vs. Basic TnT isoform expression (levator coccygeus muscle) was evaluated on Force and stiffness responses to Ca2+ (shift of approximately 0.15 in pCa50). Adult chicken breast muscle fibers expressing acidic TnT isoforms showed significantly increased sensitivity to Ca2+ of force and stiffness compared to fibers expressing solely basic TnT isoforms.
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