Key result
Oral factor Xa inhibitors substantially interfere with chromogenic anti-Xa assays but have lesser effects on aPTT or PT, suggesting aPTT may be preferable during transitions to i.v. heparin.
Why the study?
How do oral factor Xa inhibitors affect the accuracy of anti-Xa assays versus aPTT during transition to i.v. unfractionated heparin?
How do oral factor Xa inhibitors affect the accuracy of anti-Xa assays versus aPTT during transition to i.v. unfractionated heparin?
When transitioning patients from oral factor Xa inhibitors to i.v. unfractionated heparin, aPTT may be a more accurate monitoring assay than anti-Xa due to residual drug interference.
No takes yet. Share an insight, caveat, or question.
May favor aPTT over anti-Xa for heparin transitions after oral Xa inhibitors; leaves open prospective validation before practice change.
Faust et al. (2016) conducted a review in Patients transitioning from oral factor Xa inhibitors to i.v. unfractionated heparin. Oral factor Xa inhibitors (apixaban, edoxaban, rivaroxaban) was evaluated on Interference with anticoagulation monitoring tests. Oral factor Xa inhibitors substantially interfere with chromogenic anti-Xa assays but have lesser effects on aPTT or PT, suggesting aPTT may be preferable during transitions to i.v. heparin.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: