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April 1, 1958CirculationOpen Access

Carotid Sinus Participation in Experimental Renal Hypertension

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Why the study?

Do carotid sinus baroceptor reflexes adapt to higher pressure levels in experimental renal hypertension?

Population

Dogs with experimental chronic and acute renal hypertension

Design

Preclinical

Authors

JMJ. W. McCubbinInternational Academy of Business and New Technologies

Discussion

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Implication

Baroreflex resetting may sustain hypertension; leaves open human translation and therapeutic relevance.

Key Points

  • The aim is to investigate how carotid sinus baroreceptor reflexes respond to chronic renal hypertension.
  • Used direct electroneurographic techniques on acutely hypertensive dogs to assess carotid sinus activity.
  • Monitored the adaptation of baroreceptor reflexes to chronic pressure levels in renal hypertension.
  • Baroreceptor reflexes remain functional at elevated pressure levels in chronic renal hypertension.
  • Significant neurogenic vasoconstriction was observed, suggesting a role of carotid sinus in maintaining blood pressure.
  • Resetting of the baroreceptor reflex starts early but lags behind the rise in arterial pressure.

Structured PICO

Do carotid sinus baroceptor reflexes adapt to higher pressure levels in experimental renal hypertension?

P
Population
Dogs with experimental chronic and acute renal hypertension
I
Intervention
Direct electroneurographic measurement of carotid sinus baroceptor reflexes
O
Outcome
Adaptation or resetting of carotid sinus baroceptor reflexes to higher pressure levelssurrogate

In experimental renal hypertension, carotid sinus baroceptors reset to higher pressure levels, providing a physiological explanation for neurogenic vasoconstriction in chronic hypertension.

Cite This Study

J. W. McCubbin (1958) studied this question.

synapsesocial.com/papers/6a20dad16fcc58ca6c17fe16https://doi.org/10.1161/01.cir.17.4.791

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baroceptor Function in Chronic Renal Hypertension1956 · 379 citations
  2. 2Control by the Superior Cervical Ganglion of the State of Contraction and Pulsatile Expansion of the Carotid Sinus Arterial Wall1954 · 52 citations
  3. 3Local Application of Epinephrine to Carotid Sinus1955 · 9 citations
  4. 4SINOAORTIC REGULATORY SYSTEM1953 · 43 citations
  5. 5Circulatory Changes Produced by the Valsalva Maneuver in Normal Subjects, Patients with Mitral Stenosis, and Autonomic Nervous System Alterations1954 · 55 citations