What question did this study set out to answer?

To determine whether carotid sinus baroreceptor resetting in two-kidney, one-clip renal hypertension is driven by alterations in carotid sinus wall compliance or intrinsic receptor neural properties.

October 1, 1987AJP Regulatory Integrative and Comparative Physiology

Partition of carotid baroreceptor response in two-kidney renal hypertensive dogs

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Population

Dogs with two-kidney one-clip Goldblatt hypertension

Comparison

Two-kidney one-clip Goldblatt hypertension model vs Control dogs

Design

Preclinical

Follow-up

10 weeks

Authors

EKEsmail KoushanpourNorthwestern University RBRahim BehniaRush University

Discussion

Member takes

Implication

Caution against clinical translation in hypertension; extends mechanistic evidence for receptor-level baroreceptor resetting in animal models.

Key Points

To determine whether carotid sinus baroreceptor resetting in two-kidney, one-clip renal hypertension is driven by alterations in carotid sinus wall compliance or intrinsic receptor neural properties.
Constricted the left renal artery by 70–80% using a Goldblatt clamp in dogs under halothane anesthesia, leaving the contralateral kidney untouched.
Assessed animals ten weeks post-procedure by simultaneously recording whole nerve action potentials (N) and carotid sinus volume (V) across step changes in intrasinus pressure (P).
Mean blood pressure rose to 151 ± 6 mmHg in hypertensive dogs compared with 105 ± 5 mmHg in normotensive controls.
The nerve activity versus intrasinus pressure (N vs. P) curve exhibited a sigmoid shape and shifted toward higher pressures in hypertensive dogs, whereas sinus wall compliance (V vs. P) showed no significant difference compared to controls.
The composite nerve activity versus sinus volume (N vs. V) relationship shifted toward higher volumes, confirming that baroreceptor resetting is mediated by altered receptor properties rather than changes in vascular wall compliance.

Structured PICO

Population

Dogs with two-kidney one-clip Goldblatt hypertension (left renal artery constricted 70-80% with a Goldblatt clamp)

Intervention

Two-kidney one-clip Goldblatt hypertension model

Comparator

Control dogs

Outcome

Mechanism of carotid sinus baroreceptor resetting (partitioning between carotid sinus wall compliance and receptor neural elements), measured by whole nerve action potentials (N) and carotid sinus volume (V) during step changes in intrasinus pressure (P)surrogate

In a canine model of renal hypertension, carotid sinus baroreceptor resetting appears to be driven by changes in receptor neural properties rather than alterations in carotid sinus wall compliance.

Cite This Study

Koushanpour et al. (1987) studied this question.

synapsesocial.com/papers/6a728246f44fa9f079dff7b6 https://doi.org/10.1152/ajpregu.1987.253.4.r568

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Implication

Caution against clinical translation in hypertension; extends mechanistic evidence for receptor-level baroreceptor resetting in animal models.

Partition of carotid baroreceptor response in two-kidney renal hypertensive dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Partition of carotid baroreceptor response in two-kidney renal hypertensive dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider