Why the study?
Does intravenous infusion of class I and III antiarrhythmic drugs alter electrophysiological parameters in a goat model of chronic atrial fibrillation?
Does intravenous infusion of class I and III antiarrhythmic drugs alter electrophysiological parameters in a goat model of chronic atrial fibrillation?
In a goat model of chronic AF, the antifibrillatory effect of class I and III drugs appears to be driven by a widening of the temporal excitable gap rather than prolongation of the atrial wavelength.
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Temporal excitable gap widening may drive class I/III drug effects in goat AF; leaves open translation to human mechanisms or therapy.
Wijffels et al. (2000) studied this question.
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