Key result
In goats with persistent atrial fibrillation, the success rate of cardioversion by flecainide and cibenzoline decreased over 16 weeks (from 60% to 17% and 80% to 63%, respectively).
Why the study?
Does the duration of persistent atrial fibrillation reduce the efficacy of Class IC drugs for cardioversion in a goat model?
Does the duration of persistent atrial fibrillation reduce the efficacy of Class IC drugs for cardioversion in a goat model?
The progressive loss of efficacy of Class IC drugs for cardioverting prolonged AF is due to an increase in the critical AF cycle length required, rather than decreased myocardial sensitivity to the drugs.
Authors
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May limit Class IC cardioversion in prolonged AF; hypothesis-generating for critical cycle length threshold in remodeling.
Eijsbouts et al. (2006) studied Persistent atrial fibrillation (n=10). Flecainide and cibenzoline was evaluated on Success rate of cardioversion. In goats with persistent atrial fibrillation, the success rate of cardioversion by flecainide and cibenzoline decreased over 16 weeks (from 60% to 17% and 80% to 63%, respectively).
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