March 23, 2004AJP Heart and Circulatory Physiology

Introgression of chromosome 13 in Dahl salt-sensitive genetic background restores cerebral vascular relaxation

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Population

Isolated middle cerebral arteries of Dahl salt-sensitive rats, Brown Norway rats, and consomic rats having…

Comparison

Introgression of chromosome 13 from BN rats into… vs Dahl S rats, BN rats, and SS-16(BN) rats

Design

Preclinical

Authors

IDInes DrenjančevićKlinički bolnički centar Osijek JLJulian H. LombardMedical College of Wisconsin

Discussion

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Implication

Chromosome 13 introgression restores cerebral vasodilation in salt-sensitive rats; extends mechanistic models of renin-angiotensin regulation but leaves open human translation.

Structured PICO

Population

Isolated middle cerebral arteries of Dahl salt-sensitive (S) rats, Brown Norway (BN) rats, and consomic rats having chromosome 13 or 16 of the BN rat substituted into the Dahl S genetic background (SS-13(BN) and SS-16(BN))

Intervention

Introgression of chromosome 13 (containing the renin gene) from BN rats into Dahl S genetic background (SS-13(BN) rats)

Comparator

Dahl S rats, BN rats, and SS-16(BN) rats

Outcome

Vasodilation in response to ACh (10(-6) mol/l) and hypoxia (Po(2) reduction to 40-45 mmHg)surrogate

Restoration of normal renin-angiotensin system regulation via chromosome 13 introgression restores impaired cerebral vascular relaxation mechanisms in Dahl salt-sensitive rats.

Cite This Study

Drenjančević et al. (2004) studied this question.

synapsesocial.com/papers/6a20e12fb9c39a5cf6ecb580 https://doi.org/10.1152/ajpheart.01087.2003

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Implication

Chromosome 13 introgression restores cerebral vasodilation in salt-sensitive rats; extends mechanistic models of renin-angiotensin regulation but leaves open human translation.

Introgression of chromosome 13 in Dahl salt-sensitive genetic background restores cerebral vascular relaxation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Introgression of chromosome 13 in Dahl salt-sensitive genetic background restores cerebral vascular relaxation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider