Key result
Transfer of the renin gene from Dahl R into Dahl SS rats restored middle cerebral artery dilation to acetylcholine and hypoxia, but not to iloprost.
Why the study?
Does introgression of the Dahl R renin gene restore cerebral vascular relaxation in Dahl salt-sensitive rats?
Population
Isolated middle cerebral arteries from Dahl salt-sensitive rats, S/renRR renin congenic rats, and Dahl…
Comparison
Introgression of the Dahl R renin gene into the… vs Dahl SS rats and Dahl R rats
Design
Preclinical
Authors
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Renin allele substitution restores MCA relaxation in SS rats; leaves open genetic mechanisms of cerebrovascular dysfunction in human hypertension.
Does introgression of the Dahl R renin gene restore cerebral vascular relaxation in Dahl salt-sensitive rats?
Restoration of normal renin-angiotensin system regulation via renin gene introgression restores acetylcholine- and hypoxia-induced cerebral vascular relaxation in salt-sensitive rats, though prostacyclin signaling remains impaired.
Drenjančević et al. (2009) studied Impaired cerebral vascular relaxation. Transfer of the renin gene from the Dahl R strain into the Dahl SS genetic background vs. Dahl SS rats and Dahl R rats was evaluated on Responses to vasodilator stimuli in isolated middle cerebral arteries. Transfer of the renin gene from Dahl R into Dahl SS rats restored middle cerebral artery dilation to acetylcholine and hypoxia, but not to iloprost.
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